Where were you when I established the earth? (Job 38:4).
One who reads the book of Job cannot but have compassion for just and pious Job, who appears to be unfairly subjected to suffering. All the rational arguments that his friends offer to account for his innocent suffering appear hollow, and the only acceptable answer is God's remark to Job, "Where were you when I established the earth?"
In other words, a human being can see only a tiny fragment of the universe, an infinitesimally small bit of time and space. Our vantage point is much like a single piece of a huge jigsaw puzzle, a tiny fragment of the whole picture, which makes no sense on its own. Only when the entire puzzle is assembled do we realize how this odd-shaped piece fits properly. Since no human being can have a view of the totality of the universe in both time and space, we cannot possibly grasp the meaning of one tiny fragment of it.
This explanation does not tell us why the innocent may suffer, but only why there cannot be a satisfactory explanation. Acceptance of suffering therefore requires faith in a Creator who designed the universe with a master plan in which everything that happens has a valid reason. This belief may not comfort a sufferer nor prevent the sufferer from becoming angry at the Designer of the universe. The Torah does not in fact condemn the anger of the sufferer (Bava Basra 16b), but does require that he accept adversity with trust that God is just (Deuteronomy 32:4).
Acceptance does not mean approval, but it does allow us to avoid the paralyzing rage of righteous rage, and to go on with the business of living.