In 1523, the first printed edition of Tzror HaMor, a Bible commentary by Rabbi Avraham Sebag, was published in Venice. He had been expelled from Spain in 1492, and made the unfortunate choice of fleeing to Portugal, where he was persecuted and saw his two sons forcibly baptized and taken from him. He buried his manuscripts to save them from confiscation and destruction. (Alas, he never saw them again.) Rabbi Sebag eventually made his way to Africa where he managed to rewrite some of his works. It was this edition of Tzror HaMor that was published in 1523. (source: Abraham Bloch)